Welcome to the Journal of Neurology & Neuromedicine

Manuscript Guidelines

The journal has specific rules to formatting a manuscript that authors should adhere to before shipping their manuscript. These guidelines are primarily intended to make the submission of manuscript quick and easy.    Read More

click here

Ethics & Disclosures

Journal of Neurology and Neuromedicine is primarily based on values centered on loyalty, commitment, scientific accuracy, and ethics. It has adopted clear and rigorous ethical guidelines for best working practices.    Read More

What happens next to your Submission

Each article we publish benefits from hundreds of hours of work by Chief editors, Sectional editors, Reviewers, Manuscript editors, Proofreaders, Graphics and Web experts, who work to ensure that the manuscript meets our standards. Read More

cover-image

Focus & Scope


The overarching goal of the Journal of Neurology and Neuromedicine is to remain as a credible source of neurological sciences based information encompassing a variety of relevant areas such as clinical studies, cellular and molecular studies, disease mechanisms, diagnostic approaches, epidemiology, medical aspects, computational studies and treatment options of the most common neurobiological complexities with an emphasis on research that is genetically, structurally, physiologically and pathophysiologically relevant.

The integral part of our scholarly mission is to ensure the accuracy of journal quality in accord with the highest standards of professional ethics.

“Quality is our Priority.
It is the Foundation of our Publication

Read more

e-Submission

Recent Articles


Vol 4-1 Review Article

Light-Field Microscopy: A Review

Oliver Bimber* and David C. Schedl

Faculty of Engineering and Natural Sciences, Johannes Kepler University Linz, 4040, Austria

Light-field microcopy (LFM) supports single-shot volumetric recording and instant 3D excitation. It is an emerging technology for fast wide-field 3D imaging of neuronal activity, and has the potential to enable scanless 3D photostimulation for applications in optogenetics. This article introduces the basics of light-field technology, reviews the LFM principles and current implementations, summarizes first applications for optical imaging and photostimulation of neural activity, and outlines alternatives that go beyond LFM.

DOI: 10.29245/2572.942X/2019/1.1237 View / Download Pdf View Full Text
Vol 4-1 Mini Review

Treatment of Parkinsons Disease after the Wearing Off Sets in

Yoshikuni Mizuno

Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan

In 2018, we wrote a paper on the drug treatment of Parkinson?s disease. In this article, we obtained that the wearing off was observed in 77%, but the incidence of dyskinesia was 37.7% for the Parkinson?s disease patients from the onset of the disease 16-20 years. In this review article, we will discuss some of the newer treatments of Parkinson?s disease first, i.e., transplantation with induced pluripotent stem cell-derived cells, gene therapy, deep brain stimulation, levodopa/ carbidopa intrajejunal gel infusion, MRI-supported focused ultrasound, and IPX066. Then, we will discuss our opinion on the mechanism of wearing off and dyskinesia, and modifications of levodopa treatment after the wearing off sets in.

DOI: 10.29245/2572.942X/2019/1.1241 View / Download Pdf View Full Text
Vol 4-1 Mini Review

The Role of Oxidative Stress in Cocaine Addiction

Tehila Beiser, Rami Yaka*

Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, 91120, Israel

Cocaine is a powerfully addictive psychostimulant that elevates dopamine (DA) levels in the mesolimbic system and causes a feeling of wellbeing. At the same time, cocaine leads to toxic effects in many essential organs, including the brain. The harmful effects of cocaine on the brain are the basis for the development of compulsive and irrational behaviors, an integral part of cocaine addiction. Over the last two decades, it has been suggested that the damage and reinforcing properties of cocaine are associated with increased reactive oxygen species (ROS) production. This increase impairs the endogenous defense antioxidant system, either directly by cocaine metabolites, or indirectly via increased DA metabolites, resulting in oxidative stress (OS). It was thus plausible to seek an exogenous, stable and non-toxic antioxidant, which can penetrate the blood brain barrier and counteract the oxidative damage in the brain caused by drugs of abuse such as cocaine. In this mini-review we describe studies that explore the role of antioxidants in reducing the OS state in the brain reward system and consequently reversing negative behavioral outcomes induced by cocaine.

DOI: 10.29245/2572.942X/2019/1.1239 View / Download Pdf View Full Text
Vol 4-1 Review Article

Amylin Signaling in Diabetes and Alzheimer's Disease: Therapy or Pathology?

John Grizzanti1, Rachel Corrigan1, Spencer Servizi1, Gemma Casadesus1,2*

1School of Biomedical Sciences, Kent State University, Ohio, USA

2Department of Biological Sciences, Kent State University, Ohio, USA

Growing evidence highlights the intimate relationship between type II diabetes (T2D) and Alzheimer’s disease (AD). Importantly, these two diseases share a number of pathological similarities, including amyloid accumulation, oxidative stress, inflammation, and cell death. To date, drug therapies for AD and T2D are lacking and there is a crucial need for the discovery and development of novel therapeutics for these diseases. A number of human and rodent studies have given evidence that metabolic hormone supplementation is highly valuable for improving cognitive function and overall metabolic health in both T2D and AD. The pancreatic hormone amylin has arisen as a crucial component of the disease etiology of both T2D and AD, though the exact role that amylin plays in these diseases is not yet well understood. Here, we critically review the current literature that utilizes human amylin or its synthetic analogue, pramlintide, as well as amylin receptor antagonists for the treatment of AD.

DOI: 10.29245/2572.942X/2019/1.1212 View / Download Pdf View Full Text
Click here for more articles

Special Features to Authors

Editing Services

We offer editing services to help you prepare a submission-ready manuscript.
Learn more

Article Outreach

The journal works hard to maximize the impact of published research.
Learn more

Reprints

JNNM offers a professional quality Reprint Service that enables users to have reprints delivered to their door at an affordable value.
Learn more